What foods to avoid while on Eliquis?

Drugs Health News

Eliquis (Apixaban) is a medication used for preventing serious blood clots from forming owing to after hip/knee replacement surgery or a certain abnormal heartbeat (atrial fibrillation). With atrial fibrillation, fraction of the heart fails to beat the way it must. This may give rise to the formation of blood clots, which may travel to other body parts (like the lungs or legs) or increase your risk for stroke.

Also, the medication is approved to treat some types of blood clots (deep vein thrombosis-DVT, pulmonary embolus-PE) and to prevent them getting produced again. Read more to know about what foods to avoid while on Eliquis?

What does Eliquis do?

What does Eliquis do
What does Eliquis do?

Eliquis is a brand-name prescription medication and is approved by the FDA to treat and prevent hazardous blood clots that might block blood vessels in your body.

Precisely, Eliquis can be used in adults to:

  • Treat DVT, which is a blood clot that produces in a vein deep inside your body.
  • Prevent stroke and blood clots in individuals with nonvalvular atrial fibrillation (NVAF).
  • Treat PE, which is a blood clot that inhibits blood flow to your lungs.
  • Prevent DVT that might cause PE in individuals who’ve had hip or knee replacement surgery.
  • Prevent DVT or PE from recurring. After a patient has had initial treatment for a DVT or PE, Eliquis aids to prevent blood clots from recurring.

If you want to know what foods to avoid while on Eliquis, read further.

How does Eliquis work?

How does Eliquis work
How does Eliquis work?

Eliquis is an anticoagulant medication or a blood thinner. It acts by blocking factor Xa, which is a clotting factor present in the blood that helps clots to form.

It is also known as Xa inhibitor. Due to this activity on FXa, Eliquis makes blood less likely to clot.

If you are thinking what foods to avoid while on Eliquis, the answer is given at the end of this blog.

Who can take Apixaban?

Who can take Apixaban
Who can take Apixaban?

Eliquis is a prescription medication that is used to prevent blood clots from forming in people who have atrial fibrillation and are also at risk for developing a blood clot.

Eliquis is also used for the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE). Know more to understand about what foods to avoid while on Eliquis?

Apixaban is safe for people who:

  • Does not have liver or kidney diseases
  • Does not have a stomach ulcer
  • Do not have a hypersensitive reaction to Apixaban or any other drug
  • Does not have any injuries that are presently bleeding a lot, like a wound
  • Does not have antiphospholipid syndrome. It is a condition that has an effect on the immune system and makes you more likely to get blood clots
  • Did not have a recent spinal injury or surgery
  • Did not have surgery to replace a heart valve

It is vital to inform your doctor about all other drugs you are taking, including OTC drugs, vitamins, and herbal supplements, as they might interact with Eliquis. In addition, Eliquis might interact with other drugs used for treating atrial fibrillation (Afib) or DVT/PE. Keep on reading to know about what foods to avoid while on Eliquis?

What are the side effects of Eliquis?

Side Effects of Eliquis
Side Effects of Eliquis

The most common mild side effects of Eliquis can be:

  • Bleeding
  • Bruising more easily than normal
  • Anemia
  • Fatigue

More serious side effects of Eliquis can be:

  • Bleeding
  • Allergic reaction
  • High risk of blood clots on stopping the use of Eliquis early
  • Blood clots in your spine with spinal techniques.

Below is mentioned what foods to avoid while on Eliquis?

What to eat while on Eliquis?

What to eat while on Eliquis
What to eat while on Eliquis?

Apart from knowing what foods to avoid while on Eliquis, it is essential to know what to eat with Eliquis? Vitamin K-rich food items may decrease the efficacy of Warfarin, since it inhibits the effects of vitamin K in the blood.

Yet, Apixaban does not depend on the Vitamin K-dependent clotting pathway, and in its place works on clotting factor Xa. Consequently, Eliquis levels and efficacy are not changed by vitamin K consumption from foods like kale, spinach, broccoli, or brussels sprouts.

A lot of patients put on Eliquis initially have underlying heart problems. As such, a diet with ample of fruits, veggies, and nuts can be chosen over fast foods, red meat, or refined sugars. The AHA has some diet suggestions online.

What foods to avoid while on Eliquis?

You must avoid the use of grapefruit or grapefruit juice unless your healthcare provider instructs otherwise. It is good to talk to the concerned doctor about other foods that can interact with Eliquis and increase the risk of bleeding.

Eliquis does not show interaction with coffee and leafy greens that are found to contain high levels of vitamin K which may have an effect on a different anticoagulant called warfarin (Coumadin and Jantoven) that requires your body to keep a stability between the concentrations of vitamin K and warfarin in your system.

What foods to avoid while on Eliquis, these are the foods:

Luckily, Eliquis has not been found to have a bad interaction with any food items. The general culprits when it comes to the topic of food-drug interactions, including coffee, leafy greens, grapefruit juice, peppermint tea, or cranberry juice are safe to enjoy while consuming Eliquis. Following are the foods to avoid while on Eliquis:

Caffeine products (Limit Caffeine):

Limit Caffeine
Limit Caffeine

No direct interaction is seen between caffeine and Eliquis. Yet, a lot of patients taking Eliquis also have coronary artery disease (CAD), and often such people have limits put on their caffeine consumption by their doctor.

It was concluded that caffeine has the capacity to inhibit the metabolism of warfarin and enhance its plasma concentration and hence anticoagulant effects. Thus, patients should be advised to limit the frequent use of caffeine-rich products i.e. tea and coffee during warfarin therapy.

High-Fat Foods:

High Fat Foods
High Fat Foods

A diet rich in fast foods, saturated fats, or red meat are found to promote fatty plaques in your blood vessels. And, this may enhance the risk of heart disease and stroke.

High consumption of fat causes obesity, diabetes, heart disease, and possibly cancer, therefore low-fat diets are optimal. Processed carbohydrates have negative effects on metabolism; lower-carbohydrate or ketogenic diets with high fat content are better for health.

Also, obesity increases your risk of stroke and blood clots. Obese people with diet rich in fats are the same patients that are expected to end up on Eliquis.

Vitamin K containing foods:

Vitamin K containing foods
Vitamin K containing foods

Data also suggests that vitamin K interacts adversely with apixaban in your body. This is due to the reason that vitamin K supplements or foods rich in vitamin K are found to thicken the blood.

Apixaban thins the blood and dissolves blood clots, hence people must avoid foods containing vitamin K to let apixaban do its task. These foods involve green tea, cranberry juice, Brussels sprouts, spinach, and grapefruit juice.

In addition, grapefruit juice comprises compounds that may offset the activity of blood thinners, which may cause increased bleeding for a few patients. Thus, it is better to adhere to a heart-healthy diet, with fruits, vegetables, nuts, and soluble fiber. Soluble fiber is found to reduce the levels of blood cholesterol, which may reduce the risk of atherosclerosis (fatty deposits) in the blood vessels.

Next in what foods to avoid while on Eliquis, are the herbs and supplements to avoid with Eliquis:

Also, it is vital to be careful while using drugs such as ibuprofen, naproxen, and diclofenac, which are collectively called as nonsteroidal anti-inflammatory drugs (NSAIDs), while using Eliquis. NSAIDs and aspirin together may cause an increased risk of bleeding when taken in combination with blood thinners like Eliquis.

Herbal Medicines:

Herbal Medicines
Herbal Medicines

St, John’s Wort should also be avoided while taking Eliquis. The combination can reduce the effectiveness of Eliquis. Other herbs that are not safe to be taken with Eliquis include turmeric, ginger, herbal teas, or gingko biloba.

Since herbals and supplements are not approved by the FDA just as other prescription drugs, it can be hard to come by quality data on likely interactions between herbal drugs and prescription drugs. It is good to look for a medical advice from your doctor before taking herbal or vitamin supplements.

There is some data that turmeric, ginger, ginkgo biloba, or some Chinese herbs may increase the risk of bleeding when taken with an anticoagulant like Apixaban. In addition, St. John’s wort is seen to reduce the efficacy of Apixaban.


Does Eliquis Cause Leg Weakness?

Yes, Eliquis causes leg weakness. So, it is better to inform the doctor right away if you experience tingling, numbness, or muscle weakness, particularly in your legs and feet. Avoid the use of other medications unless they have been discussed with your healthcare provider.

Why is Eliquis so expensive?

Brand name medications cost more as compared to their generic versions. Presently, since the generic medication, Apixaban is not available in the U.S., American clients have to buy brand name Eliquis and give more for their prescription medications.

How long does Eliquis stay in your system?

Eliquis is found to have a half-life of 12 hours and is seen to stay in your system for nearly 24 hours after your last dose.

When will generic Eliquis be available?

Generics for Eliquis were lately approved, but they might not be available until 2026 because of a patent dispute.

What type of pain medication is safe with Eliquis?

You may consume Paracetamol while on Apixaban. Avoid taking Aspirin or Ibuprofen while using Apixaban unless the concerned doctor approves it.

How long to hold Eliquis before surgery?

Eliquis must be discontinued at least 48 hours before elective surgery or invasive procedures with a moderate or high risk of undesirable or clinically significant bleeding. In this blog, you got an understanding on what foods to avoid while on Eliquis.