Valdoxan (Agomelatine)

Valdoxan is an atypical antidepressant. It is a serotonin agonist and antagonist, meaning it works by both increasing serotonin levels and by blocking serotonin receptors. This dual action is what makes Valdoxan unique and effective in treating depression.

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Brand Choices

Brand Valdoxan 25mg
Product of Australia Australia Flag
Prescription Required
Manufactured by Servier
Brand Valdoxan 25mg
Product of United Kingdom United Kingdom Flag
Prescription Required
Manufactured by Servier
Brand Valdoxan 25mg
Product of Turkey Turkey Flag Shipped from Mauritus
Prescription Required
Manufactured by Servier

Generic Alternatives

Generic Equivalent to Valdoxan 25mg
Product of India India Flag
Prescription Required
Manufactured by Sun Pharmaceuticals

Valdoxan (Agomelatine) : Medication Information


Reviewed by : Dr. Smriti Gupta

PhD in Biochemistry, M.Sc

What is Valdoxan (Agomelatine)?

Valdoxan is a prescription medicine that belongs to a class of medications known as antidepressants. Valdoxan was prescribed to you to treat your depression or persistent mood disturbance that interferes with daily life in adults.

What is Valdoxan (Agomelatine) used for?

Valdoxan is a prescribed medicine that is meant to be used with a doctor's prescription and is used to treat depression or to help prevent depression from recurring. Depression symptoms like chronic unhappiness, loss of interest in favorite activities, feelings of hopelessness, sleep problems, a sense of being slowed down, anxiety, Changes in your weight, daily sleep, and hunger patterns can be seen to improve after using this Valdoxan can also help regulate your 'body clock' (circadian rhythm), with good effects on mood and sleep.

How does Valdoxan (Agomelatine) work?

Valdoxan's active ingredient, agomelatine, is an antidepressant. It operates in two ways. it stimulates the MT1 and MT2 receptors in the brain and it blocks the 5-HT2C receptors which cause an increase in the neurotransmitters dopamine and noradrenaline.

Direction for Use:

How to take Valdoxan (Agomelatine)?

This is an oral pill that is taken after food. Avoid crushing, chewing, smashing, or opening the capsule; instead, consume it whole. It is normally recommended that you take this medication exactly as directed by your doctor. It is often advised to take it once a day with some water In the evening before going to bed.

What is the different dosage available for Valdoxan (Agomelatine)?

The dosage is offered as an oral tablet of 25mg, depending on the line of treatment chosen.

What is the recommended dosage for Valdoxan (Agomelatine)?

The recommended dosage of Valdoxan (Agomelatine) is 25mg oral tablet once a day before bedtime.

What is the maximum dosage for Valdoxan (Agomelatine)?

Your doctor may recommend a maximum dosage of Valdoxan as 50-mg tablets to be taken simultaneously in the evening before going to bed. You should not exceed the maximum suggested daily intake of 50 mg.

What if you forget to give a dose of Valdoxan (Agomelatine)?

Get the missed dose as soon as you recall. If the next dose is approaching, skip the missed dose and resume your usual dosing schedule.

Precautions for Valdoxan (Agomelatine):

What should you know about Valdoxan (Agomelatine) before you start taking it?

Following are the precautions:

  • Tell your doctor or pharmacist if you are allergic to Valdoxan or Agomelatin or if you have any additional allergies.

  • Tell your doctor or pharmacist about your medical history, especially if you have: any liver illness or kidney disease. Monitor your liver enzyme levels with a routine blood test to ensure normal functioning of the liver.

  • Inform your doctor If you have ever had unusually 'high' feelings or dementia.

  • Inform your doctor if you frequently drink a lot of alcohol or even if you are on any other medication support. This includes any drugs that can be purchased without a prescription, as well as herbal and complementary treatments.

Side-Effects of Valdoxan (Agomelatine):

What are the side effects of Valdoxan (Agomelatine)?

Some common side effects are:

  • Headache

  • Sleepiness

  • Insomnia

  • Dizziness

  • Nauses

  • Diarrhea

  • Vomiting

  • Tiredness

  • Anxiety

Some Severe side effects include:

  • Suicidal ideation or behavior

  • Pins, and needles in the fingers and toes (paraesthesia) from a migraine

  • Restless legs syndrome

  • Sweating excessively

  • Eczema

  • Hives

  • Anger

  • Irritation

  • Aggressive Behavior

Interaction with Valdoxan:

Does this medication interact with other drugs, foods, or alcohol?

Valdoxan (Agomelatine) belongs to an antidepressant class of medicines. It should be avoided to use any other antidepressant while taking this medication. Agomelatine is a CYP1A2, CYP2C9, and CYP2C19 substrate. Inhibitor of these enzymes, such as the SSRI antidepressant fluvoxamine should also be avoided with Valdoxan since its reduce clearance and hence increase agomelatine sensitivity. It may also interact with alcohol, thereby increasing the risk of hepatotoxicity.


How should this medication be stored?

Valdoxan (Agomelatine) should be kept at room temperature (15oC-30oC) and away from light, heat, moisture, and children's access.

Other Important Information:

  • Inform your doctor if you have ever suffered or are experiencing an episode of bipolar disorder, mania or hypomania (extreme upward mood swings or irritable mood), dementia, or any other mental illness.

  • Consult your doctor about how much alcohol you consume. People who consume an excessive amount of alcohol should avoid using Valdoxan. Excessive alcohol consumption can lead to liver problems and exacerbate depression.

  • Inform your doctor if you are a regular smoker or smoke more than 15 cigarettes per day.

  • Inform your doctor if you are pregnant, plan to become pregnant, or are nursing.


How long does it take to become acclimated to Valdoxan?

Valdoxan begins to work on depression symptoms in the majority of depressed persons within two weeks after starting medication. Your depression should be treated for at least six months to guarantee that you are rid of symptoms.

What effects does Valdoxan have on your body?

In depression and/or anxiety, Valdoxan can help regulate your 'body clock' (circadian rhythm), with good effects on mood and sleep. Your doctor may prescribe Valdoxan for reasons other than treating your depression and/or anxiety.

Is it possible to stop taking Valdoxan?

Valdoxan does not induce withdrawal symptoms when stopped and can be withdrawn without the requirement for a tapering dose.

How long can I use Valdoxan?

You should take it every day for several months, and at least six months after you feel better. You should continue to take it for as long as your doctor instructs you to.

Is It Safe To Buy Valdoxan From an Online Pharmacy?

If you are looking to buy Valdoxan or any prescription drugs from an Online Pharmacy in the USA then you can order from a safe and accredited International pharmacy like MedsEngage, which contracts with Canadian Pharmacy and pharmacy in India. You require a valid prescription for your prescription drugs.

Is Valdoxan Coupon Available?

Take advantage of this Valdoxan Coupon, available only at our Canadian Pharmacy Online! We help lower your Brand and Generic Valdoxan price with our helpful Pharmacy coupons. For coupons, please visit our Prescription Coupon page.

What is the mode of buying Valdoxan (Agomelatine) online?

It is now easy to buy Valdoxan (Agomelatine) by placing an order at MedsEngage Pharmacy. People can directly place the order at or can chat with our customer care representatives. For more information, people can visit the How to Order page on

How can patients get Valdoxan (Agomelatine) Online?

Yes, licensed doctors advise Valdoxan (Agomelatine) online after a medical evaluation. Patients can speak to their online physicians to get more knowledge about the disease. Physicians give a prescription to their patients and after patients can share the prescription for Valdoxan (Agomelatine) with us via email, fax or upload over the website.

Is a prescription required for Valdoxan (Agomelatine)?

As we are a Certified Canadian pharmacy online so we required a prescription for Valdoxan (Agomelatine) that can only be bought with a prescription provided by doctor. While processing the order for Valdoxan (Agomelatine), it is better to get a valid prescription from the concerned healthcare provider. The copy of the prescription can be scanned, emailed, or uploaded directly at MedsEngage.

What is the maximum quantity of Valdoxan (Agomelatine) that can be ordered?

90-days supply is the maximum amount of Valdoxan (Agomelatine) that can be ordered online from MedsEngage at a time. The quantity is based upon the directions and amount stated in the provided medical prescription. Refilling of medication is also there for future conditions.

How about the safety of ordering Valdoxan (Agomelatine) online from MedsEngage?

As a certified Canadian Pharmacy, MedsEngage is a totally safe and secure online way to order Valdoxan (Agomelatine). It works similarly just like any conventional pharmacy. MedsEngage Pharmacy serves safe and reasonable prescription medications to individuals. You just only need to have your prescription of Valdoxan (Agomelatine) from a licensed doctor.

What about coupons for Valdoxan (Agomelatine)?

Yes, coupons for Valdoxan (Agomelatine) are available at MedsEngage Pharmacy. Valdoxan Coupons offer an extra discount to people to save their expenses on medicines. People can make use of the coupon code mentioned on the MedsEngage pharmacy coupon page. They can use the Valdoxan (Agomelatine) coupon at checkout to attain swift discounts so that they can pay less for their prescription.

Is there any option for delivering medicines to the United States?

Yes. MedsEngage Pharmacy ships medications all around the United States of America. Once the medicine has been dispatched, the customer receives an email notification on their registered email id.

Does MedsEngage Pharmacy have an option of express shipping?

An express shipping option is present with MedsEngage Pharmacy for Valdoxan (Agomelatine). The expedited delivery time to ship medicines is seven to twelve business days. People can check this option at the checkout page while processing their order of Valdoxan (Agomelatine).

What is the procedure for refilling a prescription?

It is easy and time-saving to get a refill of Valdoxan (Agomelatine) with MedsEngage. By just going to the reorder section of MY Account Tab, customers can simply put a refill for their medicine. Also for ordering a refill, you can call us or chat with customer support.

Does MedsEngage Pharmacy have an auto-refilling option for prescriptions?

MedsEngage Pharmacy does not automatically refill prescriptions for Valdoxan (Agomelatine). As it can be the case where a person no longer requires similar medication or the concerned doctor might go for dose adjustments or other factors. Yet, there is a refill reminder service available with us.

Overall Customer Reviews

4.6 Overall Satisfaction Rating

Based on 1,251 Ratings












United States

Highly recommend.

I've had consistently great experiences for almost 2 years with this company. My cost for this medication after insurance would be $800+ monthly. Ordering from medsengage is easy and affordable. Highly recommend.

Sharon McClain

United States

No dissatisfaction here.

The service from MedsEngage is awesome. Happy to have been able to save money on this very expensive prescription. No dissatisfaction here.

Carolyn Alexander

United States

I am very pleased with MedsEngage

I am very pleased with MedsEngage. The only time my order was late was during Covid-19, and that was understandable. Thank you

Barb Pittman

United States

My prescription actually arrived sooner

My prescription actually arrived sooner than I had expected. Prices are great! My only negative would be that I wish I could use Visa or Mastercard.

Mark Leisen

United States

I highly recommend them

I’ve been getting prescriptions from Meds Engage for several years now. Always great customer service and quality products at really good prices! I highly recommend them.

Stephen Cockrum

United States

It has been a pleasure doing business with this company

It has been a pleasure doing business with this company. Their products are competitively priced, the shipping is fast and seamless, the packaging is of a quality so as to protect the product. Additionally their customer service department has always been very responsive and comprehensive.

Fred Morgan

United States

I have been dealing with ME for four years

I have been dealing with ME for four years. The price for my presciption in the USA is $1500. I get the exact same thing through ME for $150. Shiping can sometimes take 30 days, but my last order got here in 10 days. Thanks ME for your good work!

Barb Combs

United States

I have had medications prepared by Meds Engage for many years

I have had medications prepared by Meds Engage for many years! Service is very accurate! Prices are less for same quantity of medication in stores here. I recommend the service of Meds Engage. You will be glad you changed!

Timothy Stearns

United States

My wife uses this pharmacy to get her seizure meds at a price

My wife uses this pharmacy to get her seizure meds at a price we can afford now that we are on Medicare. They are excellent to work with. Great service, timely deliveries. Thank you for making our lives easier.

Important Note: We do not dispense any prescription medicine without valid and legible prescription written by your local Physician. All prescriptions must be presented from a verifiable and licensed physician.

We are only able to ship a maximum 90-day supply of your prescription.

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