Combigan (Brimonidine/Timolol)

Combigan (brimonidine tartrate/timolol maleate ophthalmic solution) is a fixed-dose combination of an alpha-2 adrenergic receptor agonist and a beta-adrenergic receptor blocker indicated for the lowering of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. The two active ingredients in Combigan, brimonidine tartrate and timolol maleate, work together to lower IOP by reducing aqueous humor production and increasing aqueous humor outflow through the trabecular meshwork.

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Brand Choices

Brand Combigan 0.2/0.5%
Product of India India Flag
Prescription Required
Manufactured by Allergan
Brand Combigan 0.2/0.5%
Product of Canada Canada Flag
Prescription Required
Manufactured by Allergan
Brand Combigan 0.2/0.5%
Product of United Kingdom United Kingdom Flag
Prescription Required
Manufactured by Product of UK

Generic Alternatives

Generic Equivalent to Combigan 0.2/0.5%
Product of India India Flag
Prescription Required
Manufactured by Cipla Ltd

Brand Choices

Brand Combigan 0.2/0.5%
Product of India India Flag
Prescription Required
Manufactured by Allergan
Brand Combigan 0.2/0.5%
Product of Canada Canada Flag
Prescription Required
Manufactured by Allergan
Brand Combigan 0.2/0.5%
Product of United Kingdom United Kingdom Flag
Prescription Required
Manufactured by Product of UK

Generic Alternatives

Generic Equivalent to Combigan 0.2/0.5%
Product of India India Flag
Prescription Required
Manufactured by Cipla Ltd

Combigan (Brimonidine/Timolol) : Medication Information


Reviewed by : Dr. Smriti Gupta

PhD in Biochemistry, M.Sc

What is Combigan (Brimonidine)?

The prescription drug Combigan treats the symptoms of elevated intraocular pressure (IOP) in people with glaucoma or ocular hypertension. It is possible to take Combigan alone or in combination with other medications. Combigan is a medication in the Antiglaucoma, Combos category.

What is Combigan (Brimonidine) used for?

This medicine is used to treat glaucoma (open-angle type) and other eye conditions that cause high pressure inside the eye (such as ocular hypertension). Reducing excessive intraocular pressure makes it easier to avoid blindness.

How does Combigan (Brimonidine work?

Combigan (Brimonidine) is a medication that combines two different medications. As an alpha agonist, Brimonidine reduces the creation of fluid within the eye, thereby assisting in draining fluid from the eye. The beta-blocker medication timolol lowers eye pressure by blocking beta receptors and reducing the amount of fluid in the eyes.

Direction for Use:

How to take Combigan (Brimonidine)?

There should be a 12-hour break between doses of Combigan, which should be taken twice daily. Taking Combinigan twice a day, with a 12-hour gap between doses, is recommended. Combigan should be taken at least 5 minutes after taking any other eye medication. Be sure to keep your hands clean before using eye drops. Don't touch the tip of the dropper and don't let it come in contact with your eye or any other surface to avoid contamination.

What is the different dosage available for Combigan (Brimonidine)?

It is an ophthalmic solution eye drop of 5ml of 0.2%, 10ml of 0.5%, 15ml of 0.2%/0.5%.

What is the recommended dosage for Combigan (Brimonidine)?

The recommended dosage of Combigan is one drop in the damaged eye(s) twice daily, at a time interval of around 12 hours.

What if you forget to give a dose of Combigan?

Try to take the dose as soon as you remember. If you have missed the dose and if the next dose comes up, skip the missing dose and return to your usual dosing plan. In order to catch up on a missing dose, do not take a double dose.

Precautions for Combigan (Brimonidine):

What should you know about Combigan (Brimonidine) before you start taking it?

If you are allergic to brimonidine, timolol, or apraclonidine, or if you have any other allergies, tell your doctor or pharmacist before using this medicine.
Notify your doctor or healthcare professional about your medical information, particularly if you do have any lung disease like severe chronic obstructive pulmonary disease-COPD or asthma certain different kinds of heart palpitations, and cardiovascular diseases like heart failure, cardiac arrhythmias), kidney problems, liver damage, or any other condition.

Side-Effects of Combigan (Brimonidine):

What are the side effects of Combigan (Brimonidine)?

Some common side effects are:

  • Temporary blurred vision

  • Temporary burning, itching or redness of the eyes

  • Watery Eyes

  • Dry Eyes

  • Dry Mouth

  • Headache

  • Dizziness or Drowsiness

Interaction with Combigan:

Does this medication interact with other drugs, foods, or alcohol?

Combigan has been shown to lower blood pressure. While using a beta-blocker, your blood pressure may drop too low. This can result in hazy vision, dizziness, or fainting, which can be harmful.
Since Combigan contains a beta-blocker, you should avoid taking any other beta-blockers while taking it (timolol). This is attributed to the reason that both medications work in the same way and can elevate the chances of risk associated with low blood pressure.


How should this medication be stored?

Combigan must be stored in a tightly-closed container away from light at room temperature, heat, and humidity, and within reach of children. There is no need to refrigerate Combigan eye drops.

Other Important Information:

  • Usage of this medication without a doctor’s prescription is strictly prohibited.

  • Children under the age of two are not recommended with the use of Combigan.

  • Inform your doctor about all of your medical conditions like COPD, a significant cardiac ailment like "AV block," severe heart failure, or slow heartbeats that have caused you to pass out.

  • Do not increase your dose, take this medicine more frequently than prescribed, or stop taking it even for a short period of time without your doctor's permission.


Is Combigan capable of lowering blood pressure?

Combigan is capable to assist in lowering your blood pressure. Combigan is an ophthalmic droplet that may be used to treat one or both eyes. As a drop of a small amount, it can easily enter the bloodstream via your eyes. The compounds in Combinigan circulate throughout the body and lower blood pressure.

Will Combigan be able to help me cure my eye problems?

No, Combigan will not help you with your glaucoma or your ocular hypertension (high pressure in the eye). There is currently no cure for these two illnesses. Combigan, on the other hand, should be working on lowering your eye pressure. If your eye pressure is lower, you will be less likely to suffer long-term side effects from your illness, such as vision loss.

Is it okay if I wear contacts during my Combigan treatment?

While taking Combigan, you may use contact lenses, but you must remove them before taking the drug. Insert your contacts at least 15 minutes after each Combigan dose. This should help prevent the lens's preservative from being absorbed by your contacts.

Can I use Combigan three times a day?

Administering Combigan three times a day is more effective and safe than taking it twice a day.

What can I do to control my glaucoma or excessive intraocular pressure?

To help you control your glaucoma or excessive eye pressure, your doctor may prescribe an eye drop. Combigan is one alternative.

Is It Safe To Buy Combigan From an Online Pharmacy?

If you are looking to buy Combigan online or any prescription drugs from an in the USA then you can order from a safe and accredited International pharmacy like MedsEngage, which contracts with Canadian Pharmacy and pharmacy in India. You require a valid prescription for your prescription drugs.

What is the mode to buy Combigan online?

It is now easy to buy Combigan online by placing an order at MedsEngage Pharmacy. People can directly place the order at or can chat with our customer care representatives. For more information, people can visit the How to Order page on

How can patients get Combigan (Brimonidine / Timolol) Online?

Yes, licensed doctors advise to buy Combigan online after a medical evaluation. Patients can speak to their online physicians to get more knowledge about the disease. Physicians give a prescription to their patients and after patients can share the prescription for Combigan (Brimonidine / Timolol) with us via email, fax or upload over the website.

Is a prescription required for Combigan (Brimonidine / Timolol)?

As we are a Certified Canadian pharmacy online so we required a prescription for Combigan (Brimonidine / Timolol) that can only be bought with a prescription provided by the doctor. While processing the order for Combigan (Brimonidine / Timolol), it is better to get a valid prescription from the concerned healthcare provider. The copy of the prescription can be scanned, emailed, or uploaded directly at MedsEngage.

What is the maximum quantity of Combigan (Brimonidine / Timolol) that can be ordered?

90-day supply is the maximum amount of Combigan (Brimonidine / Timolol) that can be ordered online from MedsEngage at a time. The quantity is based on the directions and amount stated in the provided medical prescription. Refilling of medication is also there for future conditions.

How about the safety of ordering Combigan (Brimonidine / Timolol) online from MedsEngage?

As a certified Canadian Pharmacy, MedsEngage is a totally safe and secure online way to order Combigan (Brimonidine / Timolol). It works similarly just like any conventional pharmacy. MedsEngage Pharmacy serves safe and reasonable prescription medications to individuals. You just only need to have your prescription of Combigan (Brimonidine / Timolol) from a licensed doctor.

Is there any option for delivering medicines to the United States?

Yes. MedsEngage Pharmacy ships medications all around the United States of America. Once the medicine has been dispatched, the customer receives an email notification on their registered email id.

Does MedsEngage Pharmacy have an option of express shipping?

An express shipping option is present with MedsEngage Pharmacy for Combigan (Brimonidine / Timolol). The expedited delivery time to ship medicines is seven to twelve business days. People can check this option at the checkout page while processing their order of Combigan (Brimonidine / Timolol).

What is the procedure for refilling a prescription?

It is easy and time-saving to get a refill of Combigan (Brimonidine / Timolol) with MedsEngage. By just going to the reorder section of the MY Account Tab, customers can simply put in a refill for their medicine. Also for ordering a refill, you can call us or chat with customer support.

Does MedsEngage Pharmacy have an auto-refilling option for prescriptions?

MedsEngage Pharmacy does not automatically refill prescriptions for Combigan (Brimonidine / Timolol). As it can be the case where a person no longer requires similar medication or the concerned doctor might go for dose adjustments or other factors. Yet, there is a refill reminder service available with us.

Overall Customer Reviews

4.6 Overall Satisfaction Rating

Based on 1,251 Ratings












United States

Highly recommend.

I've had consistently great experiences for almost 2 years with this company. My cost for this medication after insurance would be $800+ monthly. Ordering from medsengage is easy and affordable. Highly recommend.

Sharon McClain

United States

No dissatisfaction here.

The service from MedsEngage is awesome. Happy to have been able to save money on this very expensive prescription. No dissatisfaction here.

Carolyn Alexander

United States

I am very pleased with MedsEngage

I am very pleased with MedsEngage. The only time my order was late was during Covid-19, and that was understandable. Thank you

Barb Pittman

United States

My prescription actually arrived sooner

My prescription actually arrived sooner than I had expected. Prices are great! My only negative would be that I wish I could use Visa or Mastercard.

Mark Leisen

United States

I highly recommend them

I’ve been getting prescriptions from Meds Engage for several years now. Always great customer service and quality products at really good prices! I highly recommend them.

Stephen Cockrum

United States

It has been a pleasure doing business with this company

It has been a pleasure doing business with this company. Their products are competitively priced, the shipping is fast and seamless, the packaging is of a quality so as to protect the product. Additionally their customer service department has always been very responsive and comprehensive.

Fred Morgan

United States

I have been dealing with ME for four years

I have been dealing with ME for four years. The price for my presciption in the USA is $1500. I get the exact same thing through ME for $150. Shiping can sometimes take 30 days, but my last order got here in 10 days. Thanks ME for your good work!

Barb Combs

United States

I have had medications prepared by Meds Engage for many years

I have had medications prepared by Meds Engage for many years! Service is very accurate! Prices are less for same quantity of medication in stores here. I recommend the service of Meds Engage. You will be glad you changed!

Timothy Stearns

United States

My wife uses this pharmacy to get her seizure meds at a price

My wife uses this pharmacy to get her seizure meds at a price we can afford now that we are on Medicare. They are excellent to work with. Great service, timely deliveries. Thank you for making our lives easier.

Important Note: We do not dispense any prescription medicine without valid and legible prescription written by your local Physician. All prescriptions must be presented from a verifiable and licensed physician.

We are only able to ship a maximum 90-day supply of your prescription.

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